바이오및뇌공학과 뇌인지 공학 프로그램

세미나

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* ABSTRACT:

 

Microbes living and interacting with host cells in the human gut are essential to human health. Changes in the composition of this gut microbiome cause disease-associated symptoms, which motivates the engineering of microbes to diagnose, treat, memorize, or prevent disease. Microbes reprogrammed using advanced DNA-based recording systems are envisaged as emerging living diagnostics and therapeutics for a wide range of diseases and play key roles in regulating gut microbiota to treat disease in a non-invasive manner. Here, we present a CRISPR-aided genetic switch that uses various Cas effectors to convert the mRNA information into RNA-guided transcriptional regulation or base editing. We combined the transcription factor-based genetic circuit with the CRISPR system and optimized the genetic switch performance by tuning and processing the gRNA. We then developed a DNA-based recording system for sensing and recording multiplex inflammation markers. These strategies developed here present a simple and robust approach to convert many biological signals into a DNA-based recording system, expanding the toolkit for biotechnological applications. 

 

Keywords: CRISPR-BE, Genetic circuit, Gut inflammation, DNA recording 

 

 

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  1. [Department Seminar 학과 정기 세미나 안내] (10/11, Wed) Prof. Hirohide Saito

  2. [Department Seminar 학과 정기 세미나 안내] (11/01, Wed) Prof. Hee Chan Kim

  3. [Department Seminar 학과 정기 세미나 안내] (11/08, Wed) Prof. Su-Hyun Kim

  4. BBE/BCE Departmental Seminar for Fall Semester 2023

  5. [Department Seminar 학과 정기 세미나 안내] (11/15, Wed) Prof. Ain Chung

  6. [Department Seminar 학과 정기 세미나 안내] (8/30, Wed) Prof. Kwang-Hyun Cho

  7. [Starting 4:30 PM , Wednesday, May 24 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, DongWon Kim

  8. [Department Seminar 학과 정기 세미나 안내] (9/13, Wed) Prof. Jaebum Choo

  9. [Starting 4:30 PM , Wednesday, May 17 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023,DaeHee Lee

  10. [Starting 4:30 PM , Wednesday, May 3 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, SungJune Kim

  11. [Starting 4:30 PM , Wednesday, June 7 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, SungMin Son

  12. [Starting 4:30 PM , Wednesday, April 26 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Jangyeon Park

  13. [Department Seminar 학과 정기 세미나 안내] (10/4, Wed) Prof. Hyeon Min Bae

  14. [Starting 4:30 PM , Wednesday, April 12 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, YongKeun Park

  15. [Starting 4:30 PM , Wednesday, April 5 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Hyndoo Hwang

  16. [Department Seminar 학과 정기 세미나 안내] (11/22, Wed) Prof. Yong Taik Lim

  17. BBE Departmental Seminar for Fall 2022

  18. [Starting 4:30 PM , Wednesday, November 16 / Venue: YBS Bldg. #207] BBE Departmental Seminar for Fall Semester 2022

  19. BBE/BCE Departmental Seminar for Spring 2023

  20. [Starting 4:30 PM , Wednesday,September 28 / Online ZOOM] BBE Departmental Seminar for Fall Semester 2022

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