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New ways to fight diseases with quantitative biology 

 The Son lab, established at KAIST BBE just six months ago, is dedicated to pioneering innovative methods for pathogen and human disease detection. We utilize and engineer nature's immunity to create unique molecular and cellular sensors applicable for both clinical and point-of-care applications. Our interdisciplinary approach combines cell and molecular engineering, advanced imaging techniques, and high-throughput analyses. In this presentation, I will discuss two primary areas of our ongoing research: CRISPR diagnostics and immune cell sensing. 

Our research on CRISPR diagnostics centers on the bacterial immune system component, CRISPR-Cas13, which has evolved to detect foreign RNA. This RNA sensor holds potential for a convenient and programmable in-vitro RNA sensor. I have previously demonstrated that Cas13a detection can function without necessitating nucleic acid amplification, and it can interface with a smartphone-based reader for a simple, quantitative, point-of-care SARS-CoV-2 detection. Currently, we are developing a microfluidic high-throughput platform to enhance Cas13's sensing capabilities further. Simultaneously, we aim to create an assay that can detect over ten viruses at once, in the simplest manner conceivable, with the intent to address global health challenges. 

We are also actively engaged in uncovering and applying a novel immune cell sensing mechanism. Although the individual receptor activation of immune cell-cell contact is well understood, the coordinated sensing by a group of cell surface proteins and glycoproteins remains elusive. I have previously developed an imaging method capable of measuring cell surface protein height with 1-nm resolution and demonstrated that molecular height significantly influences immune cell sensitivity to its target cell. At the Son lab, we are developing innovative measurement capabilities and devising a cell-cell interface engineering method to understand, enhance, and engineer immune cell sensing, in pursuit of next-generation immunotherapy. 

 

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List of Articles
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24 [Starting 4:30 PM , Wednesday, November 16 / Venue: YBS Bldg. #207] BBE Departmental Seminar for Fall Semester 2022 file admin 2022.11.17 381
23 [Starting 4:30 PM , Wednesday, November 23 / Venue: YBS Bldg. #207] BBE Departmental Seminar for Fall Semester 2022 file admin 2022.11.17 387
22 [Starting 4:30 PM , Wednesday, December 07 / Venue: YBS Bldg. #207] BBE Departmental Seminar for Fall Semester 2022 file admin 2022.12.07 453
21 BBE/BCE Departmental Seminar for Spring 2023 file admin 2023.02.27 384
20 [Starting 4:30 PM , Wednesday, March 8 / Venue: YBS Bldg. #207] BBE Departmental Seminar for Spring Semester 2023, Yoonkey Nam file admin 2023.03.06 390
19 [Starting 4:30 PM , Wednesday, March 15 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Sun Kim file admin 2023.03.08 523
18 [Starting 4:30 PM , Wednesday, March 22 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Jongmin Choi file admin 2023.03.16 474
17 [Starting 4:30 PM , Wednesday, March 29 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Junsang Doh file admin 2023.03.23 411
16 [Starting 4:30 PM , Wednesday, April 5 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Hyndoo Hwang file admin 2023.03.30 170
15 [Starting 4:30 PM , Wednesday, April 12 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, YongKeun Park file admin 2023.04.06 155
14 [Starting 4:30 PM , Wednesday, April 26 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, Jangyeon Park file admin 2023.04.13 103
13 [Starting 4:30 PM , Wednesday, May 3 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, SungJune Kim file admin 2023.04.21 73
12 [Starting 4:30 PM , Wednesday, May 17 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023,DaeHee Lee file admin 2023.05.15 69
11 [Starting 4:30 PM , Wednesday, May 24 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, DongWon Kim file admin 2023.05.15 59
» [Starting 4:30 PM , Wednesday, June 7 / Venue: YBS Bldg. #207] BCE Departmental Seminar for Spring Semester 2023, SungMin Son file admin 2023.05.26 90
9 BBE/BCE Departmental Seminar for Fall Semester 2023 file admin 2023.08.23 48
8 [Department Seminar 학과 정기 세미나 안내] (8/30, Wed) Prof. Kwang-Hyun Cho file admin 2023.08.23 57
7 [Department Seminar 학과 정기 세미나 안내] (9/13, Wed) Prof. Jaebum Choo file admin 2023.09.07 63
6 [Department Seminar 학과 정기 세미나 안내] (10/4, Wed) Prof. Hyeon Min Bae file admin 2023.09.27 117
5 [Department Seminar 학과 정기 세미나 안내] (10/11, Wed) Prof. Hirohide Saito file admin 2023.10.05 35
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