바이오및뇌공학과 뇌인지 공학 프로그램

세미나

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New ways to fight diseases with quantitative biology 

 The Son lab, established at KAIST BBE just six months ago, is dedicated to pioneering innovative methods for pathogen and human disease detection. We utilize and engineer nature's immunity to create unique molecular and cellular sensors applicable for both clinical and point-of-care applications. Our interdisciplinary approach combines cell and molecular engineering, advanced imaging techniques, and high-throughput analyses. In this presentation, I will discuss two primary areas of our ongoing research: CRISPR diagnostics and immune cell sensing. 

Our research on CRISPR diagnostics centers on the bacterial immune system component, CRISPR-Cas13, which has evolved to detect foreign RNA. This RNA sensor holds potential for a convenient and programmable in-vitro RNA sensor. I have previously demonstrated that Cas13a detection can function without necessitating nucleic acid amplification, and it can interface with a smartphone-based reader for a simple, quantitative, point-of-care SARS-CoV-2 detection. Currently, we are developing a microfluidic high-throughput platform to enhance Cas13's sensing capabilities further. Simultaneously, we aim to create an assay that can detect over ten viruses at once, in the simplest manner conceivable, with the intent to address global health challenges. 

We are also actively engaged in uncovering and applying a novel immune cell sensing mechanism. Although the individual receptor activation of immune cell-cell contact is well understood, the coordinated sensing by a group of cell surface proteins and glycoproteins remains elusive. I have previously developed an imaging method capable of measuring cell surface protein height with 1-nm resolution and demonstrated that molecular height significantly influences immune cell sensitivity to its target cell. At the Son lab, we are developing innovative measurement capabilities and devising a cell-cell interface engineering method to understand, enhance, and engineer immune cell sensing, in pursuit of next-generation immunotherapy. 

 

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List of Articles
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124 Prof. Christian Wallraven "Multisensory processing of shape : a behavioral, neuroimaging and computational investigation" file admin 2015.09.23 67994
123 Prof. Samuel Andrew Hires / University of Southern California / October 8 , 4:30PM file admin 2015.10.02 58597
122 교모세포종에서 획득된 종양구와 기질세포의 잠재적 사용: 임상적 적용점 file admin 2015.07.07 58264
121 Kenji Doya "Neural implementation of model-based inference and planning" file admin 2015.08.25 54602
120 2016 봄학기 뇌인지공학프로그램 정기세미나 일정 안내 Notice for the regular seminar file admin 2016.03.16 54397
119 뇌인지공학프로그램 세미나 소식 알림게시판 생성 admin 2015.04.02 53811
118 뇌인지공학프로그램 정기세미나 안내 (연사: Yu Haoyong 교수/National University of Singapore) [5월 26일(목) 오후 4:30] file admin 2016.05.19 52480
117 [(3.14) 오후 2:30, 정문술 드림홀]<KAIST 바이오및뇌공학과 뇌인지공학프로그램의 특별세미나>석학초청강연 초대 (William T. Newsome - Stanford University) 안내 file admin 2016.03.16 52438
116 뇌인지공학프로그램 정기세미나 안내 (연사: Nitish Thakor 교수/ National University of Singapore,Johns Hopkins University) Notice for the regular seminar [3월 17일(목) 오후 4:30] file admin 2016.03.15 51975
115 뇌인지공학프로그램 정기세미나 안내 (연사: Yongyeol Ahn 교수/Indiana University,Bloomington) [6월 9일(목) 오후 4:30] file admin 2016.06.02 51946
114 뇌인지공학프로그램 정기세미나 안내 (연사: Christopher Fiorillo 교수/KAIST)[4월 7일(목) 오후 4:30] file admin 2016.04.04 51622
113 뇌인지공학프로그램 정기세미나 안내 (연사: Erik De Schutter 교수/Okinawa Institute of Science and Technology) [5월 12일(목) 오후 4:30] file admin 2016.05.04 51301
112 뇌인지공학프로그램 정기세미나 안내 (연사: Sukbin Lim 교수/New York University - Shanghai)[3월 31일(목) 오후 4:30] file admin 2016.03.23 51290
111 2016 가을학기 뇌인지공학프로그램 정기세미나 안내 Notice for the regular seminar file admin 2016.09.08 50653
110 뇌인지공학프로그램 정기세미나 안내 (연사: Minlie Huang 교수/ Tsinghua University) [11월 22일(화) 오후 4:30] file admin 2016.11.16 50553
109 뇌인지공학프로그램 정기세미나 안내 (연사: Jae Kyoung Kim 교수/ KAIST) [11월 10일(목) 오후 4:30] file admin 2016.11.08 49582
108 뇌인지공학프로그램 정기세미나 안내 (연사: Georgios Christopoulos 교수/ Nanyang Technological University) [12월 8일(목) 오후 4:30] file admin 2016.12.05 48844
107 뇌인지공학프로그램 정기세미나 안내 (연사: Kazuhisa Shibata 교수/ Nagoya University) [9월 22일(목) 오후 4:30] file admin 2016.09.20 48143
106 뇌인지공학프로그램 정기세미나 안내 (연사: Arthur Kramer 교수/ Illinois University) [10월 28일(금) 오후 2:00] file admin 2016.10.14 47929
105 2016 가을학기 뇌인지공학프로그램 비정기세미나 안내 Notice for the special seminar file admin 2016.10.28 47769
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